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Actors and Projects
Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards SystemicUnderstanding of Liver Function And Disease
Start Date: 01-01-2017
End Date: 31-12-2020
Ref: http://tisumr.soton.ac.uk
Id: TISuMR
CORDIS identification number: 207245
TISuMR will provide a novel platform to study tissues as biological systems, while providing unprecedented insight into their inner workings. It proposes the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. It focuses on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolic study of tissues at the system level.
The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.
TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease